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KMID : 0043320140370070845
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Archives of Pharmacal Research
2014 Volume.37 No. 7 p.845 ~ p.851
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Phenolic compounds with IL-6 inhibitory activity from Aster yomena
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Kim A-Ryun
Jin Qinglong
Jin Hong-Guang
Ko Hae-Ju
Woo Eun-Rhan
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Abstract
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A new biflavonoid, named asteryomenin (1), as well as six known phenolic compounds, esculetin (2), 4-O-β-d-glucopyranoside-3-hydroxy methyl benzoate (3), caffeic acid (4), isoquercitrin (5), isorhamnetin-3-O-glucoside (6), and apigenin (7) were isolated from the aerial parts of Aster yomena. The structures of compounds (1?7) were identified based on 1D and 2D NMR, including 1H?1H COSY, HSQC, HMBC and NOESY spectroscopic analyses. Compounds 2?7 were isolated from this plant for the first time. For these isolates, the inhibitory activity of IL-6 production in the TNF-α stimulated MG-63 cell was examined. Among these isolates, compounds 4 and 7 appeared to have potent inhibitory activity of IL-6 production in the TNF-α stimulated MG-63 cell, while compounds 1?3 and 5?6 showed moderate activity.
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KEYWORD
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Aster yomena Makino, Asteraceae, Asteryomenin, IL-6 inhibitory activity
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